Research Associate/Senior Research Associate, Nurix Cell Therapy and Immunology
Job DetailsThe PositionThe successful candidate will be responsible for the execution of research activities toward the development of drug-enhanced cell-based therapies for Nurix's pre clinic and clinical development programs by targeting protein fate for cancer targeted therapy and immunotherapy.
Collaborating with the Discovery Biology team, the RA/SRA will be responsible for executing preclinical studies, high quality data generation, data analysis, and interpretation of data to guide indication selection for early clinical development.
Job Responsibilities Utilize broad technical expertise in cell and tumor immunology, biochemistry, and molecular biology to investigate, develop and optimize new methods to expand mechanistic understanding of Nurix's preclinic and clinical development assets Generate and characterize human drug enhanced tumor infiltrating lymphocytes (DeTIL) using advanced methods of T cell expansion and cell culture Prioritize early small molecule drug candidates for their biological and functional characterization in enhancing immune cell proliferation, differentiation, reduce exhaustion and focus of anti-tumor DeTIL as therapeutic reagents Establishing measures of successful DeTIL process outcomes by assessment of cell product persistence utilitzing state of the art technologies including deep phenotyping (multi color flowcytometry), transcriptome analysis (Nanostring, RNAseq), TCR clonality analysis (iRepertoire) and NGS (scATACseq) to enable continuous process improvement Assess and optimizenovel cell therapy process development and potency assay development that enables a more expeditious and effective cell product Present research outcome and updates, literature review, proposal new idea or improvement suggestions Education and Skills Requirements For RA:
Bachelor's or Master's degree.
Industry experience is a plus.
For SRA:
Master's degree in Biochemistry, Cell and Molecular Biology, or related field with 6
years industry experience (or Bachelor's degree with 8
years of industry experience).
Understanding of cell biology, immunology, supporting adoptive cellular therapy as a therapeutic modality Ideally, candidate will have training and/or experience in designing and implementing in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity in addition to the other measures noted above Demonstrable experience in multi-color flow cytometry panel design and characterization of cellular subsets in human blood and tissue is strongly desired Ability to troubleshoot and interpret complex data in an independent fashion Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage Excellent interpersonal, verbal and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role Collaborative spirit and ability to work with project teams, external investigators, and contract research organizations Highly motivated, innovative, and strong team player.
Excellent time management and organizational skills required Fit with Nurix Culture and Values Strong team orientation; highly collaborative Solutions and results-oriented focus Hands-on approach; resourceful and open to diverse points of view Nurix Therapeutics, Inc.
is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.
By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( https:
//www.
nurixtx.
com/privacy-policy/ ).
Recommended Skills Assessments Biochemical Assays Biochemistry Biology Cancer Immunology Communication Estimated Salary: $20 to $28 per hour based on qualifications.
Collaborating with the Discovery Biology team, the RA/SRA will be responsible for executing preclinical studies, high quality data generation, data analysis, and interpretation of data to guide indication selection for early clinical development.
Job Responsibilities Utilize broad technical expertise in cell and tumor immunology, biochemistry, and molecular biology to investigate, develop and optimize new methods to expand mechanistic understanding of Nurix's preclinic and clinical development assets Generate and characterize human drug enhanced tumor infiltrating lymphocytes (DeTIL) using advanced methods of T cell expansion and cell culture Prioritize early small molecule drug candidates for their biological and functional characterization in enhancing immune cell proliferation, differentiation, reduce exhaustion and focus of anti-tumor DeTIL as therapeutic reagents Establishing measures of successful DeTIL process outcomes by assessment of cell product persistence utilitzing state of the art technologies including deep phenotyping (multi color flowcytometry), transcriptome analysis (Nanostring, RNAseq), TCR clonality analysis (iRepertoire) and NGS (scATACseq) to enable continuous process improvement Assess and optimizenovel cell therapy process development and potency assay development that enables a more expeditious and effective cell product Present research outcome and updates, literature review, proposal new idea or improvement suggestions Education and Skills Requirements For RA:
Bachelor's or Master's degree.
Industry experience is a plus.
For SRA:
Master's degree in Biochemistry, Cell and Molecular Biology, or related field with 6
years industry experience (or Bachelor's degree with 8
years of industry experience).
Understanding of cell biology, immunology, supporting adoptive cellular therapy as a therapeutic modality Ideally, candidate will have training and/or experience in designing and implementing in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity in addition to the other measures noted above Demonstrable experience in multi-color flow cytometry panel design and characterization of cellular subsets in human blood and tissue is strongly desired Ability to troubleshoot and interpret complex data in an independent fashion Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage Excellent interpersonal, verbal and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role Collaborative spirit and ability to work with project teams, external investigators, and contract research organizations Highly motivated, innovative, and strong team player.
Excellent time management and organizational skills required Fit with Nurix Culture and Values Strong team orientation; highly collaborative Solutions and results-oriented focus Hands-on approach; resourceful and open to diverse points of view Nurix Therapeutics, Inc.
is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.
By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( https:
//www.
nurixtx.
com/privacy-policy/ ).
Recommended Skills Assessments Biochemical Assays Biochemistry Biology Cancer Immunology Communication Estimated Salary: $20 to $28 per hour based on qualifications.
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